Amylin-mediated regulation of LRP1 by miR-103/107 impairs β-amyloid efflux.

Velmurugan Gopal Viswanathan,Han Ly,Savita Sharma,Nirmal Verma,Sanda Despa,Peter T Nelson,Larry B Goldstein,Florin Despa

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

High blood human amylin levels cause cerebral microvascular dysfunction and interferes with Aβ efflux across the BBB through miRNA-mediated LRP1 downregulation. Lowering blood amylin level in early AD could improve Aβ clearance from the brain.

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