Granulocyte-macrophage colony-stimulating factor reverses Alzheimer's disease pathology in the tgf344-AD rat model.

Md Mahiuddin Ahmed,Athena Ching-Jung Wang,Timothy D Boyd,D Adriana Solano,Anne Vielle,Neil Markham,Christina M Coughlan,Heidi J Chial,M Natalia Vergara,Huntington Potter

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Although experiments are in progress, our preliminary findings indicate that GM-CSF treatment rescues some AD pathology in TgF344-AD rats. Complete results will determine the therapeutic potential for GM-CSF/sargramostim/Leukine® not only for reducing amyloidosis, but also on other relevant pathological manifestations of AD.

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