A novel key driver gene of Alzheimer's disease impacts AD-related cognitive deficit, pathology and neuro-inflammation in sex- and APOE-specific manners.

Dongming Cai,Lei Guo,Jiqing Cao,Larry Zhang,Min Huang,Jianwei Hou,Li Zhu,Julia Tcw,Minghao Zhong,Alison M Goate,Bin Zhang

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

These results strongly support our hypothesis that lrp10 is a causal regulator gene for AD, whose expression is strongly associated with cognition performance in sex- and APOE-specific manners. Our findings further implicate a role of lrp10 in regulating microglial function and neuro-inflammation in AD.

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