25-Hydroxycholesterol modulates tau-mediated neurodegeneration and microglial chemotaxis and phagocytosis.

Justin M Long, Ainsley Tran,Javier R Serrano,Xin Bao,Chao Wang, Joseph Reznikov,Anil G Cashikar,Steven M Paul,David M Holtzman

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

25-HC appears to modulate tau-mediated neurodegeneration in an ApoE-dependent manner, especially in female mice, possibly through effects on critical microglial cellular functions. CH25H and 25-HC may be viable therapeutic targets for AD-related neuroimmune activation.

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