Contribution of Alzheimer's disease risk genes in the maintenance of endolysosomal transport regulation.
Alzheimer's & dementia : the journal of the Alzheimer's Association(2021)
摘要
Altogether, our results underscore that different upstream mechanisms could lead to similar endolysosomal dysfunctions. Our observations are also shedding light on the potential of modulating/restoring endosomal recycling regulation as a strategy to alleviate observed early endolysosomal dysfunctions at preclinical stages of AD pathogenesis.
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