Spatial pattern of R 2 relaxation rate is associated with limbic-predominant, age-related, TDP-43 encephalopathy neuropathological change (LATE-NC).

The present study demonstrated a spatial pattern of lower R relaxation rate for greater LATE-NC burden in a large community cohort of older adults. This pattern involved mainly the temporal, frontal, occipital lobes and basal ganglia. The link between R and LATE-NC may be exploited towards the development of algorithms for the prediction of this devastating, recently recognized disease entity.