Proteomic investigation of the Alzheimer's risk gene MEF2C in microglial like cells.

The identification of these partners allows for a better understanding of Mef2c regulation and function as a master regulator of microglia and AD risk. This has provided insights into the molecular processes involved in AD, and the pathways through which AD relevant biology is regulated. References: (1) Sims, R. et al. 2020. The multiplex model of the genetics of Alzheimer's disease. Nature Neuroscience 23, p. 311-322. (2) Tansey, K. E. et al. 2018. Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks. Genome Medicine 10(14).