Mechanisms underlying cognitive impairment in a mouse model of familial hypercholesterolemia: Evidences of LDLr -/- mice.

Matheus Scarpatto Rodrigues,Jade de Oliveira,Daiane F Engel,Gabriela C de Paula,Helen M Melo,Samantha C Lopes,Camila T Ribeiro,Alessandra Gonçalves Machado, Rachel Kss Bast,José Claudio F Moreira,Daniel P Gelain,Rui D Prediger, Eduardo Lg Moreira,Sergio Teixeira Ferreira,Andreza Fabro de Bem

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Cognitive impairments in LDLr-/- mice were associated with exacerbation of neuronal apoptosis, synaptic dysfunction, and microglial activation in brain regions related to memory formation, but not with significant changes in Aβ processing or levels.

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