Mapping tau burden and neuronal loss in MAPT-associated frontotemporal lobar degeneration.

Lucia Aa Giannini,Daniel T Ohm,Annemieke J M Rozemuller,EunRan R Suh,Vivianna M Van Deerlin,John Q Trojanowski, Eddie B Lee,John C van Swieten,Murray Grossman,Harro Seelaar,David J Irwin

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Heterogeneity in severity and distribution of pathology in FTLD-MAPT may in part be related to underlying mutation and tau isoform conformation, which may help improve the understanding of disease pathogenesis and progression.

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