Defining cerebral leukocyte populations in local ischemic blood samples from patients with hyperacute stroke
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM(2022)
摘要
In acute stroke, neuroinflammation can nowadays be analyzed by local cerebral aspiration of pial-ischemic blood during mechanical thrombectomy. Recently, Shaw et al. reported on differences in leukocyte subpopulations within the occluded cerebrovascular compartment. In their study, a main proportion of granulocytes was lost during isolation. By immediate analysis, we found a reproducible increase in absolute local granulocytes without variations in absolute lymphocyte and monocyte numbers. Flow-cytometric phenotyping confirmed a high proportion of granulocytes and a local shift towards CD4(+) T cells. Thus, immediate analysis appears to be critical to observe distinct local responses of leukocytes to acute ischemic stroke.
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关键词
Acute ischemic stroke, flow cytometry, immune cells, leukocytes, T cells
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