Myasthenia Gravis and Myocarditis After Administration of Pembrolizumab in a Patient With Metastatic Non-small Cell Lung Cancer and Resected Thymoma

Clinical Lung Cancer(2022)

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摘要
•This case report highlights that patients with resected thymoma are still at increased risk of immune-related adverse events and a careful discussion of the benefits and risks of immune checkpoint inhibitors (ICI) treatment is warranted.•Presence of autoantibodies pre-ICI may be predictive of a higher risk of immune-related adverse events as compared to patients who are seronegative.•There may be a role to screen for autoantibodies pre-ICI for risk stratification.
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关键词
Immune checkpoint inhibitor,myocarditis,myasthenia gravis,non-small cell lung cancer,anti-titin antibodies,anti-acetylcholine receptor antibodies
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