Establishment and validation of a recursive partitioning analysis based prognostic model for guiding re-radiotherapy in locally recurrent nasopharyngeal carcinoma patients

•A total of 531 patients with local recurrence nasopharyngeal carcinoma (lrNPC) were retrospectively reviewed.•We established and validated an integrated prognostic model for lrNPC patients.•Three risk groups were derived from an RPA model that combined rT stage and EBV DNA.•Re-radiotherapy could benefit patients in the low and intermediate-risk subgroups.•No association between re-RT and survival benefit was found in the high-risk. subgroup.