COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma

•Decreased COMMD10 induces radioresistance through intracellular Cu accumulation in HCC.•COMMD10 inhibits HIF1α/CP positive feedback loop to enhance radiosensitivity by disrupting Cu-Fe balance.•Cu accumulation upregulates CP to reduce Fe concentration and inhibit lipid peroxidation and ferroptosis.•COMMD10, HIF1α, CP and SLC7A11 might be potential new targets and predictive biomarkers of radioresistant HCC.