Relevant impact of surgery on quality of life for adolescent idiopathic scoliosis A REGISTRY- BASED TWO- YEAR FOLLOW- UP COHORT STUDY

Aims To determine the value of scoliosis surgery, it is necessary to evaluate outcomes in domains that matter to patients. Since randomized trials on adolescent idiopathic scoliosis (AIS) are scarce, prospective cohort studies with comparable outcome measures are important. To enhance comparison, a core set of patient-related outcome measures is available. The aim of this study was to evaluate the outcomes of AIS fusion surgery at two year follow up using the core outcomes set. Methods AIS patients were systematically enrolled in an institutional registry. In all, 144 AIS patients aged 5 25 years undergoing primary surgery (median age 15 years (interquartile range 14 to 17) were included. Patient-reported (condition-specific and health-related quality of life (O.oL); functional status; back and leg pain intensity) and clinician-reported outcomes (complications, revision surgery) were recorded. Changes in patient-reported outcome measures (PROMs) were analyzed using Friedman's analysis of variance. Clinical relevancy was determined using minimally important changes (Scoliosis Research Society (SRS) 22r), cut off values for relevant effect on functioning (pain scores) and a patient-acceptable symptom state (PASS; Oswestry Disability Index). Results At baseline, 65 out of 144 patients (45%) reported numerical rating scale (NRS) back pain scores > 5. All PROMs significantly improved at two year follow up. Mean improvements in SRS 22r function (+ 1.2 (SD 0.6)), pain (+ 0.6 (SD 0.8)), and self image (+ 1.1 (SD 0.7)) domain scores, and the SRS 22r total score (+ 0.5 (SD 0.5)), were clinically relevant. At two year follow up, 14 out of 144 patients (10%) reported NRS back pain > 5. Surgical site infections did not occur. Only one patient (0.7%) underwent revision surgery. Conclusion Relevant improvement in functioning, condition-specific and health-related O.oL, selfimage, and a relevant decrease in pain is shown at two year follow up after fusion surgery for AIS, with few adverse events. Contrary to the general perception that AIS is a largely asymptomatic condition, nearly half of patients report significant preoperative back pain, which reduced to 10% at two year follow up. Cite this article: Bone Joint J 2022;104-B(2):265-273.