Preventive treatment with fish oil facilitates the antidepressant-like effect of antidepressant drugs in type-1 diabetes mellitus rats: Implication of serotonergic system

Ana Paula Farias Waltrick, Alvaro Henrique Bernardo de Lima Silva,Milene Cristina de Carvalho, Bruna Aparecida Comotti de Oliveira,Katya Naliwaiko,Joice Maria da Cunha,Janaina Menezes Zanoveli

Neuroscience Letters（2022）

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摘要

•Fish oil may be a good adjunct to treat diabetes-associated depression.•Improvement of the serotonergic system appears to be crucial in the beneficial mechanism of action of fish oil.•The DHA:EPA ratio in the FO supplementation can be important to induce antidepressant-like effect.

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关键词

Omega-3 fatty acids,Docosahexaenoic acid,Eicosapentaenoic acid,Depression,Streptozotocin,Serotonin

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