The potential role of intravenous vitamin C monotherapy in critical illness.

Vitamin C is an essential micronutrient with antioxidant properties and its use in critical illness has gained interest in recent years. Four systematic reviews/meta-analyses (SRMAs) have been published in 2021 alone (see Table 1 summary). These 4 SRMAs included between 8-43 randomized controlled trials evaluating vitamin C with or without thiamine and/or corticosteroids in general ICU patients and those with sepsis and septic shock. Fujii et al performed a network meta-analysis which is a method for comparing multiple treatments using both direct and indirect evidence across trials that included studies with vitamin C monotherapy or with thiamine and/or corticosteroids. This article is protected by copyright. All rights reserved.