Current protocols and clinical efficacy of human fetal liver cell therapy in patients with liver disease: A literature review

Antonella Giancotti,Valentina D'Ambrosio,Sara Corno,Cristina Pajno,Guido Carpino,Gaia Amato,Flaminia Vena,Alessandro Mondo,Lorenzo Spiniello,Marco Monti,Ludovico Muzii,Daniela Bosco,Eugenio Gaudio,Domenico Alvaro,Vincenzo Cardinale

Cytotherapy（2022）

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摘要

•Seven clinical studies of fetal liver cell therapy were reported.•There were no RCTs, and thus no study was stratified as being of good quality.•Logistic limitations of the procedure can be reduced by cryopreservation methods.•Preclinical translational studies are necessary to answer relevant clinical questions.•Tracing strategies and biopsy-based and solid clinical endpoints are key.

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关键词

cell therapy,cirrhosis,EpCAM,fetal stem cells,obstetrics,progenitors

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