Obesity and response to biological therapy in rheumatoid arthritis: the role of body mass index and adipose tissue cytokines.

Marta Novella-Navarro,Fernanda Genre,Borja Hernández-Breijo,Sara Remuzgo-Martínez,Ana Martínez-Feito,Diana Peiteado,Irene Monjo,Miguel Ángel González-Gay,Chamaida Plasencia-Rodríguez,Alejandro Balsa

Clinical and experimental rheumatology（2022）

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摘要

Obesity influences the extent of LDA/remission in patients treated with TNFi, but not in patients treated with TCZ, probably because of underlying pathophysiological mechanisms intrinsic to the production of proinflammatory adi-pokines. Therefore, therapeutic strategies with a mechanism of action other than TNF inhibition would be more suitable for obese patients.

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关键词

rheumatoid arthritis,obesity,adipokines,tumour necrosis factor inhibitors,tocilizumab

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