Stereoselective Self-Assembly of Complex Chiral Radial [5]Catenanes Using Half-Sandwich Rhodium/Iridium Building Blocks

Herein, we have successfully achieved the stereoselective synthesis of two chiral radial [5]catenanes in a single step through the self-assembly of bidentate ligands containing L-alanine residues and binuclear half-sandwich organometallic rhodium(III)/iridium(III) clips. Remarkably, these two chiral radial [5]catenanes exhibit complex stereochemical structures as revealed by single-crystal X-ray diffraction. The eight binuclear units and eight bidentate ligands in their solid-state structures all exhibit a single planar chirality, and the interlocking between molecular macrocycles exhibits a single co-conformational mechanical helical chirality. This indicates that the introduction of the point chirality in the ligands enables the efficient stereoselective construction of mechanically interlocked molecules. Furthermore, by using ligands containing D-alanine residues, radial [5]catenanes with the opposite planar chirality and opposite co-conformational mechanical helical chirality have also been obtained.