Tigliane Diterpenoids with Larvicidal, Antifungal, and alpha-Glucosidase Inhibitory Activities from Croton damayeshu

Thirty-five tigliane diterpenoids and two ent- kaurane diterpenoids were isolated from the leaves of Croton damayeshu, and, among them, compounds 1-10 were characterized as new tigliane diterpenoids. The structures of compounds 1-10 were determined by analysis of their HRESIMS, NMR, and ECD data and by chemical methods. The isolates were assayed for their larvicidal, antifungal, and alpha-glucosidase inhibitory activities, and compounds 8-10 were found to possess larvicidal activities against Plutella xylostella with LC50 values of 0.19, 0.16, and 0.26 mu M, respectively, comparable to the LC50 of 0.14 mu M for the positive control, flubendiamide.