Longitudinal changes in the control mechanisms for blood pressure and cerebral blood flow in Alzheimer's disease: Secondary results of a randomized controlled trial

•Cerebral autoregulation and baroreflex sensitivity are two key mechanisms that regulate the homeostasis of blood pressure and brain perfusion.•For the first time, we performed repeated measurements of these mechanisms in a sample of Alzheimer's disease patients .•In this sample, we found no evidence that these mechanisms become impaired over time.•These patients did not demonstrate increased vulnerability towards starting mild blood pressure lowering therapy.•This paves the way for further studies that investigate the safety and benefits of antihypertensive treatment in Alzheimer's disease