SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria- Infected Persons, Cambodia

Jessica Manning,Irfan Zaidi,Chanthap Lon,Luz Angela Rosas,Jae-Keun Park,Aiyana Ponce,Jennifer Bohl,Sophana Chea,Maria Karkanitsa,Sokunthea Sreng,Huy Rekol,Char Meng Chour,Dominic Esposito,Jeffery K Taubenberger,Matthew J Memoli,Kaitlyn Sadtler,Patrick E Duffy,Fabiano Oliveira

EMERGING INFECTIOUS DISEASES（2022）

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摘要

Inhabitants of the Greater Mekong Subregion in Cambodia are exposed to pathogens that might influence serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey of 528 malaria-infected persons demonstrated higher-than-expected positivity of nonneutralizing IgG to spike and receptor-binding domain antigens. These findings could affect interpretation of large-scale serosurveys.

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关键词

COVID-19,Cambodia,SARS-CoV-2,coronavirus disease,cross-reactivity,malaria,serosurvey,severe acute respiratory syndrome coronavirus 2,vector-borne infections,viruses,zoonoses

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