Mechanistic understanding of metal-catalyzed oxidation of polysorbate 80 and monoclonal antibody in biotherapeutic formulations

Fethi Bensaid, Camille Dagallier,Jean-René Authelin,Héloïse Audat,Vasco Filipe, Christine Narradon,Pierre Guibal,Séverine Clavier,Pierre Wils

International Journal of Pharmaceutics（2022）

引用 8|浏览1

暂无评分

摘要

Surfactants are commonly used in biotherapeutic formulations to prevent the formation of aggregates and protect proteins from denaturation. Among them polysorbates are the most widely used. However, they are known to be prone to degradation, mainly via enzymatic hydrolysis and oxidation.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要