An Exploration of Subgroups of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Their Risks of Conversion to Dementia or Death

•What is the primary question addressed by this study?The purpose of this study was to examine neuropsychiatric symptom complexes in a population with mild cognitive impairment and assess whether these complexes were associated with more rapid progression to dementia or death without dementia.•What is the main finding of this study?In addition to a subgroup with mild or no neuropsychiatric symptoms, three subgroups were identified based on mood, hyperactive, or psychotic symptoms, and these three subgroups were at higher risk of dementia.•What is the meaning of the finding?Our results suggest that the structure of neuropsychiatric symptoms warrants further consideration in classification models of mild cognitive impairment to better predict the risk of disease progression.