Natural compound library screening identifies Sanguinarine chloride for the treatment of SCLC by upregulating CDKN1A

Mingtian Zhong,Xun Li,Fengyun Zhao,Yanni Huang,Yihao Long,Kaizhao Chen,Xuemei Tian,Ming Liu,Xiaodong Ma

Translational Oncology（2022）

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摘要

•Natural compound library screening identified Sanguinarine chloride as a tumor suppressor in SCLC.•Sanguinarine chloride exhibits anti-SCLC ability in vitro and in vivo.•Sanguinarine chloride upregulates CDKN1A to suppress SCLC development.•Sanguinarine chloride enhances the anti-tumor effect of panobinostat in SCLC by promoting cell cycle arrest.

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关键词

Natural compound,SCLC,Sanguinarine chloride,Panobinostat,CDKN1A

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