Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy (vol 81, pg 446, 2022)

Qing Cheng,William Butler,Yinglu Zhou,Hong Zhang,Lu Tang,Kathryn Perkinson,Xufeng Chen,Xiaoyin Sara Jiang,Shannon J. McCall,Brant A. Inman,Jiaoti Huang

EUROPEAN UROLOGY（2023）

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摘要

We discovered that rare tumor cells in primary prostate cancer possess genomic features of castration-resistant prostate cancer. This represents a novel resistance mechanism distinct from the widely held notion that prostate cancer becomes resistant to hormonal therapy through a therapy-induced adaptation mechanism.

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关键词

Castration-resistant prostate cancer,Primary prostate cancer,Single-cell transcriptomes,Intratumor heterogeneity,Castration-resistant prostate cancer–like cells,Evolutionary trajectory,Critical transcription regulator,Neuroendocrine differentiation,Large population validation

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