Multiparametric F-18-FDG and (68)GA-DOTATOC PET Imaging in Bone Metastatic Meningioma Before Radionuclide Therapy Assessment of Tumor Heterogeneity

This report presents the case of a 61-year-old woman with assessment of fronto-temporo-sphenoidal refractory meningioma before radionuclide therapy with pretherapeutic Ga-68-DOTATOC PET/CT. Given the discovery of osteolytic lesions, F-18-FDG PET/CT is planned to search for the primitive origin. Meningioma bone metastasis is confirmed with spine biopsies. The presence of dedifferentiated meningioma lesions indicating that high somatostatin receptor expression does not necessarily coincide with areas of increased glucose metabolism. F-18-FDG and Ga-68-DOTATOC PET/CT allows optimal characterization of tumor heterogeneity and guide targeted therapeutic management before PPRT.