Bisphenol a affects neurodevelopmental gene expression, cognitive function, and neuromuscular synaptic morphology in Drosophila melanogaster

Chloe Welch, Eden Johnson, Angelina Tupikova, Judith Anderson,Brendan Tinsley,Johnathan Newman, Erin Widman,Adam Alfareh, Alexandra Davis, Lucero Rodriguez,Clayton Visger,Justin P Miller-Schulze,Wendy Lee,Kimberly Mulligan

NeuroToxicology（2022）

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摘要

•Exposure to BPA downregulates genes involved in neurodevelopment in Drosophila.•BPA affects visual perception by impairing recognition and/or response to stimuli.•Associative learning is diminished by developmental BPA exposure.•Axonal branching within the larval neuromuscular junction is increased by BPA.

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BPA,NDD,ASD,GO,RNA-seq

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