PTEN: A novel target for vitamin D in melanoma

Artur Shariev,Nicole Painter,Vivienne E Reeve,Nikolas K Haass,Mark S Rybchyn, Furkan A Ince,Rebecca S Mason,Katie M Dixon

The Journal of Steroid Biochemistry and Molecular Biology（2022）

引用 8|浏览8

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摘要

•1,25-dihydroxyvitamin D3 reduces melanoma cell viability while increasing caspase levels.•1,25-dihydroxyvitamin D3 inhibits PI3K-AKT-mTOR and RAS-ERK signaling pathways in melanoma.•The growth inhibitory effect of 1,25-dihydroxyvitamin D3 in melanoma cell lines is dependent on PTEN and the vitamin D receptor (VDR).•1,25-dihydroxyvitamin D3 may target PTEN to reduce melanoma cell viability.•The role for vitamin D in melanoma remains unclear but it may have therapeutic benefit.

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关键词

Vitamin D3,1,25-dihydroxyvitamin D3,Melanoma,AKT,PTEN,Vitamin D receptor

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