Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer

San-Hui Gao,Gui-Zhen Wang,Li-Peng Wang,Lin Feng,Yong-Chun Zhou, Xian-Jun Yu,Fan Liang,Fu-Ying Yang,Zheng Wang,Bei-Bei Sun,Di Wang,Li-Jun Liang,Da-Wei Xie,Song Zhao,Hai-Ping Feng, Xueqing Li, Keqin Kathy Li,Tie-Shan Tang, Yun-Chao Huang,Shi-Qiang Wang

Cell Calcium（2022）

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摘要

•CACNA1E is frequently mutated in non-small cell lung cancers of both Chinese and Caucasian patients.•CACNA1E is overexpressed in non-small cell lung cancers.•CACNA1E as well as its mutants is functional as a calcium channel.•CACNA1E is able to regulate EGFR phosphorylation.•CACNA1E is required lung cancer cell proliferation in vitro and in vivo.

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关键词

CACNA1E,Non-small cell lung cancer,Intracellular calcium concentration,Cell proliferation,EGFR

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