Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel.

Reyes Maria Martín-Rojas,Ignacio Gómez-Centurión,Rebeca Bailén,Mariana Bastos,Francisco Diaz-Crespo,Diego Carbonell,Rafael Correa-Rocha,Marjorie Pion,Cristina Muñoz,Milagros Sancho, Isabel Gómez Fernández,Gillen Oarbeascoa,Ana Pérez-Corral,Carolina Martínez-Laperche,Javier Anguita,Ismael Buño,Javier Menárguez,Jose Luis Díez-Martín,Mi Kwon

Clinical case reports（2022）

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摘要

Chimeric antigen receptor (CAR) T cell-related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with poor prognosis and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR T-cell follow-up, allows a more precise management of this complication.

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