Evaluation of the incidence and clinical significance of WT-1 expression in uterine serous carcinoma

Jennifer McEachron,Agha Wajdan Baqir,Nancy Zhou,Absia Jabbar,Raavi Gupta,Daniel Levitan,Yi-Chun Lee

Gynecologic Oncology Reports（2022）

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摘要

•Approximately one-fifth of uterine serous carcinomas (USC) will express WT-1.•WT-1 expression is associated with a significant improvement in platinum sensitivity.•Improved platinum sensitivity among WT-1 positive tumors contributes to a superior PFS vs. WT-1 negative tumors.

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Uterine serous carcinoma,Wilms Tumor 1 gene

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