Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis.

M A Nielsen,D Køster,S Greisen,A Troldborg,K Stengaard-Pedersen,P Junker,K Hørslev-Petersen,M L Hetland,M Østergaard,M Hvid,H Leffler,T W Kragstrup,B Deleuran

Scandinavian journal of rheumatology（2023）

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摘要

Our findings underscore the role of Gal-3 regarding disease activity and tissue destruction in RA. An initial decrease in plasma Gal-3 levels predicted decreased long-term disease activity. Correspondingly, a Gal-3 inhibitor decreased the activity of inflammatory FLSs and osteoclastogenesis in patients with RA.

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关键词

inflammatory fibroblast activation,rheumatoid arthritis,osteoclastogenesis

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