Association of SIX1-SIX6 polymorphisms with peripapillary retinal nerve fibre layer thickness in children.

Shi Yao Lu,Xiu Juan Zhang,Yu Meng Wang,Nan Yuan,Ka Wai Kam,Poemen P Chan,Pancy Os Tam,Wilson Wk Yip,Alvin L Young,Clement C Tham,Chi Pui Pang,Jason C Yam,Li Jia Chen

The British journal of ophthalmology（2022）

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摘要

Both rs33912345 and rs10483727 at were associated with p-RNFL thickness in children, especially at the temporal-inferior sector, with age-dependent and sex-specific effects. SNP rs12436579 was associated with nasal-inferior p-RNFL thickness. Our findings suggested a role of in RNFL variation during neural retina development in childhood.

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child health (paediatrics),genetics,glaucoma,imaging,optic nerve

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