Studies of the Formation and Stability of Ezetimibe-Cyclodextrin Inclusion Complexes

In the presented studies, the interactions between ezetimibe (EZE) and selected cyclodextrins were investigated. alpha-Cyclodextrin (alpha CD), beta-cyclodextrin (beta CD) and its modified derivatives, hydroxypropyl-beta-cyclodextrin (HP beta CD) and sulfobutylether-beta-cyclodextrin (SBE beta CD), were selected for the research. Measurements were carried out using calorimetric and spectroscopic methods. Additionally, the Hirshfeld surface and biochemical analysis were achieved. As a result of the study, the inclusion complexes with 1:1 stoichiometry were obtained. The most stable are the complexes of beta-cyclodextrin and its derivatives. The comparison of beta CD with its derivatives shows that the modifications have an affect on the formation of more durable and stable complexes.