Impact of body mass index on the efficacy of aromatase inhibitors in patients with metastatic breast cancer

Rima Patel,Zhiqiang Li,Brittney S Zimmerman,Marc Y Fink,Jason D Wells,Xiang Zhou,Kristin Ayers,Arielle Redfern,Scott Newman,Eric Schadt,William K Oh,Rong Chen,Amy Tiersten

CANCER RESEARCH（2022）

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摘要

While BMI influences efficacy of AIs in the adjuvant setting, our results suggest that in the metastatic setting, BMI may not impact the efficacy of AIs. This discrepancy could be due to other differences in disease characteristics that make complete aromatase inhibition more important in the adjuvant setting when disease burden is the lowest.

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关键词

Aromatase inhibitors,Hormone positive breast cancer,Metastatic breast cancer,Obesity

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