Intrinsic factor autoantibodies by luminescent immuno-precipitation system in patients with corpus atrophic gastritis

•A novel diagnostic autoantibody test for intrinsic factor autoantibodies using a LIPS in histologically-proven CAG patients and controls.•This assay discriminated between patients and controls with a good specificity and a relatively low sensitivity that reflects the likely low prevalence of intrinsic factor antibodies in CAG.•Positivity occurred independently from anemia and vitamin B12 deficiency.•Intrinsic factor antibodies should be assessed in patients at high clinical suspicion of CAG.