The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3

Jorge Cuéllar,Josefine Vallin,Andreas Svanström,Moisés Maestro-López,María Teresa Bueno-Carrasco,W Grant Ludlam,Barry M Willardson,José M Valpuesta,Julie Grantham

Journal of Molecular Biology（2022）

引用 5|浏览12

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摘要

•Gelsolin binds to the molecular chaperone CCT but is not a folding substrate.•Gelsolin and CCT co-localise close to sites of actin rearrangements.•CCT protects gelsolin from cleavage by caspase-3.•Cryo-electron microscopy reveals gelsolin binding deep in the chaperonin cavity.•Interactions with CCT may modulate gelsolin activity and influence actin dynamics.

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关键词

chaperonin,actin,TRiC,cryoelectron microscopy,structured illumination microscopy

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