In Silico Identification of the Key Ionic Currents Modulating Human Pluripotent Stem Cell-Derived Cardiomyocytes Towards an Adult Phenotype

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a promising resource for regenerative therapies. However, their immature phenotype and heterogeneities raise concern for arrhythmia when hiPSC-CMs are inserted into the native tissue. In silico models can improve understanding of the electrophysiological differences between hiPSC-CMs and adult cardiomyocytes and inform ...