In vitro anti-synovial sarcoma effect of diallyl trisulfide and mRNA profiling

•The development of new therapeutic drug for SS treatment is urgent medical need.•Apoptosis, cycle arrest, intracellular ROS, mitochondria and autophagy were detected to identify effect of DATS on SS.•High-throughput RNA-sequencing analysis was performed to clarify a comprehensive molecular portrait for DATS-induced transcriptional regulation.•Go and KEGG analysis were performed to reveal the related molecular events induced by DATS pharmacological properties.•PPI network was conducted to identify hub genes and protein feature.