Lesson of regulatory anatomy: Using integrated functional genomics to dissect the X-inactivation center
Molecular Cell（2022）
摘要
Gjaltema et al. (2021) perform systematic screens to identify the long-sought cis-regulatory elements of Xist. They discover that distal elements give Xist a boost as cells exit pluripotency, while proximal elements restrict Xist expression to cells with two X chromosomes.
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