Cyclosporine Ameliorates Silica-Induced Autoimmune Hepatitis in Rat Model by Altering the Expression of Toll-Like Receptor-4, Interleukin-2, and Tumor Necrosis Factor-α.

Moustafa M Mohammed,Ahmed M M Okasha, Amany H Abdel Naiem, Reham F Mohamed,Sayed F Abdelwahab,Hatem A Mohamed

Current molecular medicine（2023）

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摘要

This study advocates the therapeutic role of cyclosporine in treating immune-mediated hepatic diseases. Cyclosporine improves histological alterations in the liver and inhibits the production of proinflammatory cytokines.

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关键词

Autoimmune hepatitis,NFkB,TLR-4,TNF-a,cyclosporine,interleukin 2

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