A Self-Amplifying Mrna SARS-CoV-2 Vaccine Candidate Induces Safe and Robust Protective Immunity in Preclinical Models
Giulietta Maruggi,Corey P. Mallett,Jason W. Westerbeck, Tiffany Chen,Giuseppe Lofano,Kristian Friedrich, Lin Qu, Jennifer Tong Sun, Josie McAuliffe,Amey Kanitkar,Kathryn T. Arrildt, Kai-Fen Wang, Ian McBee,Deborah McCoy, Rebecca Terry, Alison Rowles, Maia Araujo Abrahim,Michael A. Ringenberg, Malcolm J. Gains,Catherine Spickler,Xuping Xie,Jing Zou,Pei-Yong Shi,Taru Dutt,Marcela Henao-Tamayo,Izabela Ragan,Richard A. Bowen,Russell Johnson,Sandra Nuti,Kate Luisi,Jeffrey B. Ulmer,Ann-Muriel Steff,Rashmi Jalah,Sylvie Bertholet,Alan H. Stokes,Dong Yu Molecular Therapy（2022）
Key words
self-amplifying mRNA,SARS-CoV-2 vaccine,immunogenicity,biodistribution,toxicity,efficacy,spike antigen
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