RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1

Yingyun Yang,Xinyuan Cao, Lisong Huang,Aiming Yang

Molecular Immunology（2022）

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摘要

•The expression of RNF19a is increased in macrophages upon virus infection.•RNF19a selectively inhibits type I interferon production upon RNA virus infection.•RNF19a inhibits the RIG-I signaling upon RNA virus infection.•RNF19a promotes the degradation of TBK1 through K48-linked ubiquitination.

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关键词

PRR,TLR,IFN,RNF,TBK1,RIG-I,PAMP,RLR,MDA5,MAVS,TRAF,IKK,Dorfin

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