Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53.

Feng Hong,Ching Ying Lin,Jingyue Yan,Yizhou Dong,Yuli Ouyang,Doyeon Kim,Xiaoli Zhang,Bei Liu,Shaoli Sun,Wei Gu,Zihai Li

Hepatology (Baltimore, Md.)（2022）

引用 6|浏览8

暂无评分

摘要

These findings demonstrate that CNPY2 is crucial for liver oncogenesis through UPR-dependent repression of p53 and activation of oncogenes, providing insights into the design of a therapeutic target for HCC.

查看译文

关键词

CNPY2,FGF21,Hepatocellular carcinoma,c-Jun,p53,ribosome biogenesis,unfolded protein response

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要