Cytoskeleton alterations in non-alcoholic fatty liver disease

Metabolism（2022）

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摘要

•Non-alcoholic fatty liver disease (NAFLD) involves up-regulation of cytoskeleton proteins.•Keratin 18 is released from hepatocytes and can be quantified in the blood.•α-Smooth muscle actin is up-regulated in hepatic stellate cells and can be down-regulated.•These findings provide new approaches for NAFLD diagnosis and treatment.

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关键词

NAFLD,MAFLD,NAFL,NASH,HSCs,α-SMA,MAPK,PI3K,AMPK,TGFβ,MCD,LAP1,VLDV,LC3,CYP4A14

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