Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice

Jason D Meadows,Joseph A Breuer,Shanna N Lavalle, Michael R Hirschenberger, Meera M Patel,Duong Nguyen, Alyssa Kim,Jessica Cassin,Michael R Gorman,David K Welsh,Pamela L Mellon,Hanne M Hoffmann

Molecular Metabolism（2022）

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摘要

•Loss of the transcription factor Six3 in mature neurons causes dwarfism.•Six3 in neurons is required for proper functioning of the growth axis.•Six3 in the mature suprachiasmatic nucleus is required for circadian timekeeping.

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关键词

Somatostatin,Growth hormone,Metabolism,Circadian rhythm,Suprachiasmatic nucleus,Six homeobox 3

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