Blastocyst development after fertilization with in vitro spermatids derived from nonhuman primate embryonic stem cells

Sujittra Khampang,In Ki Cho, Kanchana Punyawai,Brittany Gill,Jacqueline N Langmo,Shivangi Nath,Katherine W Greeson,Krista M Symosko, Kristen L Fowler,Siran Tian,John P Statz, Alyse N Steves,Rangsun Parnpai,Michael A White,Jon D Hennebold,Kyle E Orwig,Calvin R Simerly,Gerald Schatten,Charles A Easley

F&S Science（2021）

引用 10|浏览9

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摘要

This work demonstrates that rSLCs, generated in vitro from primate pluripotent stem cells, mimic many of the capabilities of in vivo round spermatids and perform events essential for preimplantation development. To our knowledge, this work represents, for the first time, that functional spermatid-like cells can be derived in vitro from primate pluripotent stem cells.

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关键词

In vitro spermatogenesis,round spermatids,TET3,blastocysts

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