Tissue plasminogen activator for the treatment of adults with critical COVID-19: A pilot randomized clinical trial.

Farid Rashidi,Stefano Barco,Parisa Rezaeifar,Parham Sadeghipour,Samad Ghodrati,Hooman Bakhshandeh,Seyed Ali Mousavi-Aghdas,Armin Sadeghi,Akbar Sharifi,Hamed Valizadeh,Haleh Mikaeili,Farnaz Rafiee, Zahar Navarbaf, Gita Farajian,Ata Mahmoodpoor,Behnood Bikdeli,Khalil Ansarin

Thrombosis research（2021）

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摘要

•Widespread microthrombosis is considered as an etiology for impaired oxygenation in patients with COVID-19 with ARDS.•Systemic thrombolytic versus prophylactic- and therapeutic-dose anticoagulation were compared in present study.•Systematic thrombolytic therapy did not improve oxygenation in critically ill patients with COVID-19.

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