Evaluating the effect of clofazimine against Mycobacterium tuberculosis given alone or in combination with pretomanid, bedaquiline or linezolid

Sarah Kim,Arnold Louie,George L Drusano,Mohammed Almoslem,Soyoung Kim,Jenny Myrick,Jocelyn Nole,Brandon Duncanson,Charles A Peloquin,Charles A Scanga,Walter Yamada,Michael Neely,Stephan Schmidt

International Journal of Antimicrobial Agents（2022）

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摘要

•Clofazimine (CFZ) showed additive/synergistic effects in combination regimens.•CFZ alone showed the least antimicrobial efficacy among the evaluated drugs.•The effect of CFZ may be underestimated using this screening approach.•There was no correlation between the mode of interaction and antimicrobial efficacy.

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关键词

clofazimine,pretomanid,bedaquiline,linezolid,combination chemotherapy,Mycobacterium tuberculosis

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